Titlebook: Interferons and Their Applications; Paul E. Came,William A. Carter (Professor and Dire Book 1984 Springer-Verlag Berlin Heidelberg 1984 Hi

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Application of Recombinant DNA Technology to Expression of Human Interferon Genes,very in 1957. However, the lack of adequate quantities of high purity IFN has hampered basic research on the biology of IFN as well as the conduct of clinical trials to determine IFN’s practical efficacy. Both problems — quantity and purity — have been addressed and solved by the application of reco

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The Molecular Mediators of Interferon Action,rs to be discussed in this chapter are enzymes which are synthesized at an increased rate in interferon-treated cells (B. 1979). It should be pointed out that interferon induces the synthesis of several proteins in mammalian cells (Gupta et al. 1979; K. and K. 1979). These proteins can be identified

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The Cellular Effects of Interferon,nts that IFN can also have significant effects on uninfected cells. The range of these effects is extensive; the largest number of reports deals with the ability of IFN to inhibit cell growth in culture (see reviews by Gresser and Tovey 1978; Dahl 1977 b; Baron et al. 1979; Gresser 1977; Hovanessian

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Lymphoblastoid Interferon: Production and Characterization, by Finter 1973; Oxman 1973), but clinical trials have been hindered by the shortage of suitable material. Primary human leukocytes obtained from transfusion blood and processed as described by Strander and Cantell (1966,1967) have until recently provided nearly all the interferon used in humans. In

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Fibroblast Interferons: Production and Characterization,re sophisticated, and on occasion also more correct. This truism is especially applicable to the subject matter to this chapter, for much work on the production and characterisation of fibroblast interferon (IFN) was performed before it was understood that the interferon produced by fibroblast cells

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Immune Interferon, 1976). Table 1 presents the growing list of recognized lymphokines, monokines, and cytokines, including interferon, which are biologically active mediators produced by cells (G. et al. 1980 a). At present, it is not clear whether these lymphokine functions listed in Table 1 represent different mole

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Comparative Biologic Activities of Human Interferons,identification of interferon by Issacs and Lindenmann in 1957, numerous studies have been directed toward understanding the multiple effects these proteins have on cellular functions and immune responses (Stewart 1981). Although virus-induced interferons, the classical interferons, have been studied