Titlebook: Intercellular Signalling in the Mammary Gland; Colin J. Wilde,Malcolm Peaker,Christopher H. Knigh Book 1995 Springer Science+Business Medi

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Local Signals for Growth Cessation and Differentiation in the Mammary Glandlex multistage process, which begins in the embryo with the mammary . giving rise to primary and secondary sprouts. Sparsely branching ducts invade the stroma at puberty, followed by the development of lobuloalveolar structures, and functional differentiation during pregnancy (Topper and Freeman, 19

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The Role of ,-Family Genes and , Genes in Normal and Preneoplastic Mammary Epithelium, Studied by Ti and then perturb their expression. We have developed a method for expressing genes specifically in mouse mammary epithelium by reconstituting mammary epithelium from genetically manipulated cells (Edwards .., 1988; Edwards 1993). We summarise here recent results we have obtained with genes of the .

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B Induces Abnormal Patterns of Growth in Mammary Epitheliumwth factor receptor (EGFR) or .B is overexpressed in around 35% of breast tumours (Sainsbury .., 1985) but there is no evidence that this affects mammary epithelial development .. We have expressed a constitutively activated form of the EGFR, the .B oncogene from the chicken erythroblastosis retrovi

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High Density Culture of Immuno-Magnetically Separated Human Mammary Luminal Cellsures because of their greater proliferative potential. However, it is the luminal cells which are of interest in many studies since they are the source of most breast cancers. In order to study luminal cells in culture, the two cell types must be separated. This has previously been achieved using fl

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