Titlebook: Intercellular Communication in Cancer; Mustapha Kandouz Book 2015 Springer Science+Business Media Dordrecht 2015 Cancer.Cell junctions.Hom

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Beyond the Channel: Role of Connexins in Regulating Normal and Cancerous Processes in the Mammary Goordinated continuous development of the mammary gland. The dynamic remodeling of the mammary gland is orchestrated by cellular responses to environmental cues that are relayed through the interplay between cell-cell junctions themselves including tight junctions, adherens junctions, desmosomes and

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Connexins: Bridging the Gap Between Cancer Cell Communication in Glioblastoma,other advanced cancers, GBM is characterized by extensive cellular heterogeneity and is organized in a hierarchy with self-renewing, therapeutically resistant cancer stem cells (CSCs) at the apex. While communication between GBM tumor cells and their surrounding stroma supports tumor survival and ex

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MicroRNA and Gap Junctions in Glioblastoma Cells: Implications for Cellular Therapy,major cellular pathways linked to cell growth and survival, have been characterized in GBM. The frontline therapy for GBM, Temozolomide (TMZ), induces its own resistance, partly through miRNA-9. The increase in miRNA-9 decreases the translation of Patch receptor, resulting in enhanced hedgehog signa

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Cadherin-Based Cell-Cell Adhesions: Adhesion Structure, Signalling and Computational Modeling,ogenesis by modulating cell-cell adhesions in a Ca. dependent manner. In this chapter, we review the various types of cadherins, interacting partners of cadherins, the structure and assembly of cadherin-mediated cell-cell adhesions, force-sensitive nature of cadherin bonds, and the role of cadherins

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Tumor-Derived Exosomes in Metastasis Signaling and Implications,ole for exosome-mediated intercellular communications in metastasis signaling. Exosomes are specialized plasma membrane-bound nanovesicles secreted under physiological conditions by various cells to regulate tissue homeostasis and immune response. In cancer, overproduction of exosomes and/or changes

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Tunneling Nanotubes: Intercellular Conduits for Direct Cell-to-Cell Communication in Cancer,rt of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In

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