Titlebook: Innovative Medicine; Basic Research and D Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Conference proceedings‘‘‘‘‘‘‘‘ 2015 The Editor(s) (if

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Metabolic Regulation by Nuclear Receptorses in NR signaling in metabolism, with a focus on the emerging paradigm that positions NRs as hubs that translate environmental signals of a particular physiological state into daily metabolic rhythms. As NRs are a proven class of therapeutic targets, these novel findings provide insight into therapeutics for the metabolic syndrome.

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Conference proceedings‘‘‘‘‘‘‘‘ 2015or the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move

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Linear Polyubiquitination: A Crucial Regulator of NF-κB Activationnew type of polyubiquitin chain, the linear polyubiquitin chain, plays a crucial role in regulating the NF-κB activation pathway in non-degradable manner. In this chapter, the discovery, roles in NF-κB activation, and involvement in the pathogenesis of cancers of linear ubiquitination will be discussed.

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Shazia W. Sadiq,Maria E. Orlowskaay be multifactorial in nature, but the changes involved may be generally classified into those which arise because of (1) alterations in the disposition of the drug within the body and/or (2) alterations in the pharmacodynamics of the pertinent drug-receptor interactions. While there is suggestive

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Crispin GardinerThe leading reference text in the field for many years and continuously updated and expanded..Features new sections and chapters on quantitative finance, adiabatic elimination and simulation methods..

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The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor