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Pharmacogenomics of Endocrine Therapy in Breast Cancer,lt, are relatively unable to catalyze tamoxifen hydroxylation. These same subjects appear to have poorer outcomes when treated with tamoxifen than do CYP2D6 “extensive metabolizers”. These data led the US Food and Drug Administration (FDA) to hold public hearings in 2006 on the inclusion of this pha

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Adaptation to Estradiol Deprivation Causes Up-Regulation of Growth Factor Pathways and Hypersensitieatment with oophorectomy, which substantially lowers estradiol for a prolonged period, respond secondarily to aromatase inhibitors with tumor regression. We have utilized in vitro and in vivo model systems to examine the biologic processes whereby Long Term Estradiol Deprivation (LTED) causes cells

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Role of Endocrine-Genotoxic Switchings in Cancer and Other Human Diseases:,of NCD have raised the concept of ‘normal’ and ‘successful’ aging. The apparent paradox of simultaneous increase with aging of the diseases connected with estrogen deficiency as well as with estrogenic excess can be explained by the existence of the phenomenon of the switching of estrogen effects. A

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Obesity and Diabetes Epidemics:,especially in developing countries and countries undergoing economic transition to a market economy. One consequence of obesity is an increased risk of developing type II diabetes..Overall, there is considerable evidence that overweight and obesity are associated with risk for some of the most commo

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