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Titlebook: Inhibitors to Coagulation Factors; Louis M. Aledort,Leon W. Hoyer,Gilbert C. White Book 1995 The Editor(s) (if applicable) and The Author(

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Molecular etiology of factor VIII deficiency in hemophilia A the other X chromosome contains a normal gene. The frequency of the disorder is 1–2 in 10,000 male births in all ethnic groups. The severity and frequency of bleeding in the patients correlates with the F.VIII activity in plasma (Rizza et al., 1983; Hoyer, 1987).
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Porcine factor VIII therapy in patients with factor VIII inhibitorslia conducted under the auspices of the ISTH F.VIII and IX scientific standardization subcommittee. The treatment of congenital and acquired hemophilia are compared, since they differ in a number of important respects.
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Clinical presentation and management of patients with circulating anticoagulantseir patterns of occurrence, details of clinical presentations, and practical management of acute hemorrhage are difficult to gather. In an effort to augment the clinical data base, we reviewed the records of 26 patients treated at our institution from 1980 to 1993.
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