Titlebook: Inhibin, Activin and Follistatin; Regulatory Functions Toshihiro Aono (Professor and Chairman),Hiromu Sug Book 1997 Springer Science+Busine

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Effect of Activin A on the Formation of Pancreatic Endocrine Cellsd to transforming growth factor-. (TGF-.) and are considered members of the TGF-. supergene family. Activin A, a homodimer of the .. subunits of inhibin, is also an erythroid differentiation factor that induces the differentiation of Friend erythroleukemia cells (3). To identify other actions of act

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Inhibin, Activin, and Follistatin: Observations on Their Role in the Physiology of Pregnancy α-sub-unit products (5, 6), inhibin levels were shown to rise in conception cycles in contrast to the declining levels in nonpregnant cycles (7). Several studies have demonstrated that serum inhibin in pregnancy rose during the first trimester, plateaued in the second trimester, and rose again in the third trimester (8–11).

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Changes of Activin a Secretion in Gestational Diseasesetal circulation and have an endocrine effect in the physiology of pregnancy. The changes of activin and inhibin concentration in gestational biological fluids (maternal serum, umbilical cord serum, and amniotic fluid) thus reflect the changes of placental inhibin and activin synthesis and secretion.

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Follistatin Physiology and Potential Mechanisms of Action in the Human and 315 amino acids, with the 300/303 species being predominant (6,7). As each of these core proteins can have up to two N-linked carbohydrate chains, this family can contain at least six different forms of FS.

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