Titlebook: Inhibin, Activin and Follistatin; Regulatory Functions Toshihiro Aono (Professor and Chairman),Hiromu Sug Book 1997 Springer Science+Busine

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Expression of Inhibin Subunits, Follistatin, and Activin Receptors in Normal Testicular Cells and Teed activin A or B, respectively, whereas .... -dimers are named activin AB (2, 3). All subunits are synthesized as larger precursor proteins; the factors that influence combination of subunits and cleavage of the precursors are scarcely known.

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Two-Site Immunoassay for Native Inhibin A ..-subunits, and these proteins are subsequently cleaved at sites of paired basic amino acids to yield the 20-kDa α-subunit and the 15-kDa .-subunits (5–9). Activin is a .-subunit dimer and consists of inhibin ..- and ..-subunits that have been termed activin A, activin AB, and activin B (10–12).

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Production of Inhibin-Related Peptides by Ovarian Tumors0 per 100,000 women. Most patients with the disease present at an advanced stage, with 30% surviving for 5 years with a diagnosis of stage 3 epithelial malignancy (representing local and pelvic extraperitoneal spread) while only 5%–10% survive with stage 4 disease (disseminated malignancy).

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Plasma Inhibin and Activin in Diseaser-inhibin levels in various pituitary, adrenal, gonadal, and other diseases in an attempt to find the clinical significance of inhibins and their pathophysiological role. At the same time, the plasma level of free activin was measured using a competitive protein-binding assay with follistatin (8).