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Titlebook: Inhalation Toxicology; The Design and Inter Donald L. Dungworth,Georg Kimmerle,Werner Stöber Conference proceedings 1988 Springer-Verlag Ne

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Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, andbe the case for a wide range of compounds that have been tested for their toxicity to the respiratory system, whether these compounds are administered by inhalation or other systemic means. The extrapolation to humans of inhalation toxicology studies using animal models assumes comparability in the
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Different Methods Used in Acute and Subchronic Inhalation Studies of Potential Lung Irritants, with ties. Owing to the frequently high reactivity of locally irritant vapors with the moisture contained in air expired by the test species, the possibility of a secondary change of the test substance in the inhalation chamber atmosphere cannot be excluded. This factor must therefore be taken into accou
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Interspecies Dosimetry of Reactive Gasesral component of the risk assessment process. The availability of such models allows for more informed judgments of potential risk from human exposure since toxicological data obtained in a variety of animal species using different exposure regimens can be compared to humans on the basis of dose del
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Interpretation of Early Lesions in the Mouse Lung: Fibrogenesis and Tumorigenesisn qualitative and quantitative changes in lung injury and repair, but was technically demanding and time-consuming. Nevertheless, the role of the alveolar type II epithelial cell in repairing damaged pulmonary epithelium became apparent (41). Autoradiography allows the study of cell renewal in airwa
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Experimentally Induced Emphysema and Long-Term Nitrogen Dioxide Inhalationmean the disease affecting the lung parenchyma in which the air spaces are enlarged as a result of loss of tissue substance or destruction of parenchyma, but where the enlargement occurs without associated fibrosis or scarring. This enlargement of airspaces may occur with or without compromise of fu
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Comparisons of Respiratory Function Responses of Laboratory Animals and Humansdying lung physiology. These tests are a rapid, noninvasive means of providing quantitative information on the functional status of the respiratory system. Measurements of the respiratory function of animals are frequently used in studies of the toxic effects of inhaled materials, basic lung physiol
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