| 书目名称 | Influenza Virus Sialidase - A Drug Discovery Target |
| 编辑 | Mark Itzstein |
| 视频video | |
| 概述 | Covers all relevant aspects of anti-influenza virus drug discovery.Contributions by international leading scientists.A valuable source of information for researchers, clinicians and the pharmaceutical |
| 丛书名称 | Milestones in Drug Therapy |
| 图书封面 |  |
| 描述 | .Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. .This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the. .haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.. |
| 出版日期 | Book 2012 |
| 关键词 | Avian influenza; Drug design; Infectious diseases; Neuraminidase; Sialic acid; Sialidase inhibitors; Tamif |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-7643-8927-7 |
| isbn_softcover | 978-3-0348-0779-1 |
| isbn_ebook | 978-3-7643-8927-7Series ISSN 2296-6056 Series E-ISSN 2296-6064 |
| issn_series | 2296-6056 |
| copyright | Springer Basel AG 2012 |
发表于 2025-3-21 16:33:41
