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Titlebook: Inflammation and Epilepsy: New Vistas; Damir Janigro,Astrid Nehlig,Nicola Marchi Book 2021 Springer Nature Switzerland AG 2021 Brain-body

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Pro- and Anti-inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium,om the bloodstream in complex crosstalk tightly regulated by the blood-brain barrier (BBB). Two distinct inflammatory processes have been linked to seizures: neuroinflammation and systemic inflammation. Seizures can be triggered by a pathogen or dysregulated sterile immunity. . is an intrinsic brain
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Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders,e of inflammatory molecules that differs from their classical functions as immune activation effectors in infection or autoimmunity. We review the main actions exerted by inflammatory molecules on target cells by selecting those with a demonstrated role in experimental seizures and discuss their rel
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Glial Mechanisms of Inflammation During Seizures, acquisition of inflammatory properties that influence the activity and the fate of brain cells, including neurons, glia, and cells of the blood vessels. In this chapter, we review how dysregulation of astrocyte and microglia physiological functions and the emergence of specific reactive states impact epilepsy progression.
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Ketogenic Diet, Inflammation, and Epilepsy,diet not only affects seizures per se but also has the potential to attenuate or prevent the development of epilepsy and its progression. This chapter will focus on novel disease-modifying properties of ketogenic diet therapy and will discuss therapeutic challenges and opportunities.
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Book 2021apies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways..
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Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction aincluding specific cell types, inflammatory mediators as well as ECM molecules. Furthermore, we will discuss new therapeutic targets and the results of intervention studies that are important for the development of novel therapeutic approaches in epilepsy.
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Autoantibodies, Encephalopathies, and Epilepsy,cians to start early immunotherapy while awaiting results for autoantibody testing in “possible” and “probable” autoimmune encephalitis and provide criteria for the diagnosis of “autoantibody-negative but probable autoimmune encephalitis,” which may benefit from immunomodulation.
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