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Titlebook: Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence; C. J. Peters,Charles H. Calisher Conference proceedings 20

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Virus perpetuation in populations: biological variables that determine persistence or eradication,uation of acute viruses; for instance, measles required a population of 500,000 for perpetuation in the pre-measles vaccine era. Furthermore, if an acute virus, such as poliovirus, exhibits marked seasonality in large populations, then it may disappear during the seasonal trough, even in the presenc
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The virus-immunity ecosystem,ia, and are likely to have led to the extraordinary diversity of recognition molecules, the breadth in effector functions, and the persistent memory that distinguishes the vertebrate, adaptive immune system from the innate response mechanisms that operate more widely through animal biology. Both are
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Regulation of Rodent-Borne viruses in the natural host: implications for human disease,hting, increase risk of transmission of some viruses and result in different patterns of infection between male and female mice. Communal nesting may result in overwinter transmission in colder climates. (5) Physiologic factors control host response to infection and length of time the host remains i
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Control of arbovirus diseases: is the vector the weak link?,ector control strategies using pesticides have not been sustainable. New insights into vector biology and vector pathogen interactions, and the novel targets that likely will be forthcoming in the vector post-genomics era, provide new targets and opportunities for vector control and disease reductio
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,Pathogenesis of Rift Valley fever virus in mosquitoes — tracheal conduits & the basal lamina as an iers. Midgut basal lamina pore sizes are significantly smaller than arboviruses and ultrastructural evidence suggests that midgut tracheae and tracheoles may provide a means for viruses to circumvent this barrier. Further, immunocytochemical evidence indicates the existence of a salivary gland infec
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The virulence of the 1918 pandemic influenza virus: unraveling the enigma,nced virulence in 1918 could have been due to type I interferon inhibition by the NS1 protein. Results from these experiments suggest that in human cells the 1918 NS1 is a very effective interferon antagonist. Sequence analysis of the 1918 influenza virus is allowing us to test hypotheses as to the
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The spread of the H5N1 bird flu epidemic in Asia in 2004,ider the possible role of migrating birds in the evolution and spread of the H5N1 influenza A virus throughout Asia. We conclude that the available information is consistent with a role for migrating birds but limited information is available and that serological studies are urgently needed on migra
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Transient or occult HIV infections may occur more frequently than progressive infections: changing rom the HIV strains in the laboratory, indicating that they were not laboratory contaminants. Genome identity typing (“paternity-typing”) of PBMC samples obtained at the time of “early HIV Ab”-positivity, and later when Ab was absent from each of the 8 subjects, showed that blood samples were not mi
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