Titlebook: In Vivo EPR (ESR); Theory and Applicati Lawrence J. Berliner Book 2003 Springer Science+Business Media New York 2003 biochemistry.biophysic

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Pharmaceutical Applications of , EPR,and pharmacokinetics. This method offers unique opportunities to characterise delivery processes. It provides information about the microenvironment inside the drug carriers (microviscosity, micropolarity, microacidity) and permits the quantitative characterisation of release mechanisms. Localised i

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Book 2003topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrume

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Frequency and Power Considerations for , EPR and Related Techniques,on than need be, and some beneficial modifications are proposed, for example. a figure-of-eight design. Finally, some practical suggestions are given for minimising the likelihood of overheating the animal.

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Principles of Imaging,g, instrumentation, data acquisition, signal processing, and image reconstruction are discussed. Strategies for enhancement of image quality and resolution have also been discussed in this Chapter. A few examples that are representative of biological applications are presented.

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Spin Trapping in Vivo: Facts and Artifacts,heir direct detection by EPR spectroscopy is not feasible. Although specialised techniques exist for free radical generation to allow direct EPR spectroscopy, such as rapid or stopped flow, flash photolysis, and pulsed radiolysis, these have limited applications to biological systems and so other approaches are required.