Titlebook: In Vitro Toxicity Testing Protocols; Sheila O’Hare,Chris K. Atterwill Book 1995 Springer Science+Business Media New York 1995

Constrain

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jovial

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Ambiguous

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Plaque

COWER

homeostasis

Commonplace

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Hepatoma Cell Cultures as In Vitro Models for Hepatotoxicityted that hepatoma cell lines may provide an appropriate in vitro model for the assessment of likely hepatotoxicity in vivo. It should be noted, however, that the usefulness of such systems largely depends on the ability of the cells to maintain differentiated functions.

propose

The FRAME Cytotoxicity Test (Kenacid Blue)hat a cytotoxic chemical (regardless of site or mechanism of action) will interfere with this process and, thus, result in a reduction of the growth rate as reflected by cell number. The degree of inhibition of growth, related to the concentration of the test compound, provides an indication of toxicity.

Mechanics

LLC-RK1 Cell Screening Test for Nephrotoxicity cells may, therefore, be considered as potential in vivo nephrotoxins. In this test system, harmful effects on cell viability are determined by monitoring the uptake of the vital dye Neutral Red into the lysosomes of healthy cells.