Titlebook: Impacts of Medications on Male Fertility; Erma Z. Drobnis,Ajay K. Nangia Book 2017 Springer International Publishing AG 2017 Male fertilit

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Introduction to Medication Effects on Male Reproduction,dequately addressed in the evaluation of male infertility and fertility plans are rarely considered by providers before prescribing medications. In this volume, we systematically consider medications being used world-wide, focusing on those that might cause poor semen quality in men with otherwise i

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Challenges of Obtaining Evidence-Based Information Regarding Medications and Male Fertility,ional bias is introduced by failing to include other factors that influence the outcome in the experimental design. A uniform population amenable to randomization and placebo-control are experimental species, and useful information has been gained from these models. However, application to humans is

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,Male Reproductive Functions Disrupted by Pharmacological Agents,n also have direct toxicity on the seminiferous tubule epithelium, including effects on Leydig cells, Sertoli cells, or germ cells. In some cases, spermatogenesis is severely impaired. After leaving the testis, sperm spend a week or more in the epididymis. It is clear from the timing of some drug ef

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Pain Medications and Male Reproduction,s. For example, endogenous opioids produced by Leydig and germ cells provide paracrine inhibition at Sertoli cell receptors, decreasing the production of androgen binding protein, which is required for intra-testis transport of androgens. Morphine also increases the expression of aromatase in the br

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Psychotropics and Male Reproduction,on; however, testosterone levels are generally normal, reducing the likelihood of direct HPG axis inhibition by PRL. The tricyclic antidepressants have also been shown to increase PRL levels in some studies but not in others. The exception is the tricyclic antidepressant clomipramine, which profound