Titlebook: Immunotherapy of Sarcoma; Sandra P. D‘Angelo,Seth M. Pollack Book 2019 Springer International Publishing AG, part of Springer Nature 2019

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Immune Response and Immunotherapy in GISTmal tumor (GIST) and serves as a paradigm for targeted molecular therapy. However, imatinib is rarely curative, and recurrent or resistant disease often develops. Immune-checkpoint blockade is a promising new approach to cancer therapy. Correlative research in human GIST specimens has suggested that

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Regulatory T cells. Regulatory T cells (Tregs) perform a key role in mediating this immunosuppressive response via a variety of mechanisms. Tregs express FoxP3, CD4, and CD25 and they develop either in the thymus or differentiate in the periphery from naïve T cells. To this day, Treg infiltration has been shown to ha

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Radiation and Immunotherapy for Sarcomaic tumors to palliate symptoms, and is estimated to contribute to approximately 40% of cancer cures [2]. For patients with large and/or high-grade soft tissue sarcomas, radiation therapy is frequently used in the neoadjuvant or adjuvant setting to improve local control [3–5], but small randomized st

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Oncolytic Virus Immunotherapy in Sarcomal mechanism—a direct, cytotoxic effect and an indirect immune-mediated response. Because OVs are live viral particles, recombinant technologies are used to engineer safe and effective viruses that have a strong anti-tumor response yet maintain low pathogenicity towards normal host cells. Delivery of

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Immune Checkpoint Inhibitors in Sarcoma emerged as pivotal agents in the paradigm shift that we have witnessed in cancer management. The FDA has approved many of these agents to treat a variety of cancers including melanoma, lung cancer, renal and bladder cancer to name but a few. Research examining the role of immunotherapy in the manag

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Cellular Immunotherapy for Sarcomasansion and, in many cases, engineering. ACT is now at a crossroads with the potential to impact every cancer including sarcoma. The alteration of T-cell specificity by genetically modifying them to express well-characterized, high-affinity TCRs allows ACT to target cancers with normal extracellular

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ished systolic function. Clinically, DCM gives rise to fatigue, shortness of breath, and increased morbidity and mortality. DCM occurs in response to underlying pathologies including valvular dysfunction, hypertension, or myocarditis, or as an idiopathic disorder of the myocardium. Among patients wi

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Varun Monga,Seth M. Maliske,Mohammed Milhemished systolic function. Clinically, DCM gives rise to fatigue, shortness of breath, and increased morbidity and mortality. DCM occurs in response to underlying pathologies including valvular dysfunction, hypertension, or myocarditis, or as an idiopathic disorder of the myocardium. Among patients wi