Titlebook: Immunotherapy of Melanoma; Anand Rotte,Madhuri Bhandaru Book 2016 Springer International Publishing AG 2016 Melanoma.Immunotherapy.Check p

琐事

Mechanisms of Immune Evasion by Cancerlls that are harmful for host’s survival. Immunosurveillance, is a process by which immune system monitors the cells/tissues continuously and eliminates the modified or transformed cells. While the immune cells have unique abilities to detect the abnormally dividing cells, tumors also develop specia

元音

Interferon-α2bde inhibition of viral replication, activation of immune cells, and up regulation of antigen presentation by stimulating MHC antigen expression in the target cells. IFN-α is a Type I interferon which signals through IFNAR receptor complex that consists of IFNAR1 and IFNAR2; it mainly has antiprolife

Endemic

Interleukin-2e discovered. It mainly functions as a T-cell growth factor. Its discovery is considered as a major milestone in the field of immunology and the cloning of its cDNA which allowed the production of recombinant IL-2 is considered as a turning point in immunology research. IL-2 is also one of the oldes

考博

IpilimumabFDA both as an adjuvant therapy for surgically-treated ‘high-risk’ melanoma patients and as primary treatment for unresectable metastatic melanoma patients. It is a monoclonal antibody against CTLA-4, a negative regulatory receptor on T-cells. The current chapter describes potential benefits of CTLA

Customary

Nivolumabved by US FDA for the treatment of metastatic melanoma in December 2014 and its combination with ipilimumab was approved in September 2015. Nivolumab is a monoclonal antibody against the PD-1 receptor. PD-1 belongs to the immunoglobulin superfamily of proteins and is expressed on the cell surface of

LAVA

institute

Mobile

Promising Immunotherapeutic Approaches in Clinical Trialsged the academic and the industry-based scientists to continue research on immunotherapy of cancer. Apart from monoclonal antibodies, several types of strategies are developed for the treatment of melanoma and other types of cancers. Most of the strategies were found to be well tolerated and showed