Titlebook: Immunotherapy of Melanoma; Anand Rotte,Madhuri Bhandaru Book 2016 Springer International Publishing AG 2016 Melanoma.Immunotherapy.Check p

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Flavouring

Anand Rotte,Madhuri Bhandarue past three decades have from infancy through young adulthood seen in witnessed enormous advances in the under- Ann Arbor and at the current clinical sit978-1-4419-3973-9978-0-387-29170-3Series ISSN 0166-9842

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ing molecular targets and immunotherapeutic strategies under investigation.. .With 132 illustrations including synopsis tables for important information, over 1200 references (majority of which are openly acces978-3-319-83890-8978-3-319-48066-4

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Melanoma—Introduction, History and Epidemiologyes and metastatic melanoma is considered as one of the deadliest types of skin cancers. The present chapter is intended to introduce melanoma to the readers. In the beginning of the chapter, basic details of skin structure are described and the various cell types present in the top most layer of ski

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Etiologytors. In this chapter, different types of risk factors and their association with melanoma are detailed. First, UV radiation, a well-known environmental risk factor for melanoma, its characteristic features, subtypes, types of DNA damages caused and the main repair mechanisms are discussed; Xeroderm

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Dendritic Cells, process the antigens and present the antigens on MHC class I/II to T-cells along with appropriate costimulatory signals. They are the unique type of antigen presenting cells that can activate both CD8. as well as CD4. T-cells. The present chapter describes the significance of DCs in immune respons

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T-Lymphocytesypically identified by the presence of T-cell receptors (TCR), T-cells are broadly classified into CD4. T-cells and CD8. T-cells, which upon appropriate activation by DCs differentiate into respective effector cells and initiate the immune response. The current chapter presents the details of T-cell