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Titlebook: Immunosuppression under Trial; Proceedings of the 3 P. Cochat,J. Traeger,M. Derchavane Conference proceedings 1999 Springer Science+Busines

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书目名称Immunosuppression under Trial
副标题Proceedings of the 3
编辑P. Cochat,J. Traeger,M. Derchavane
视频video
丛书名称Transplantation and Clinical Immunology
图书封面Titlebook: Immunosuppression under Trial; Proceedings of the 3 P. Cochat,J. Traeger,M. Derchavane Conference proceedings 1999 Springer Science+Busines
描述Immunosuppression in solid organ transplantation is currentlyexperiencing a worldwide revival since new drugs are now available andothers are under development. In order to contribute to the design offuture strategies, a critical approach of surrogate endpoints is givenand long-term side effects are analysed, together with the impact ofnon-compliance, quality-of-life and economical parameters. In thisbook, international specialists have set up the scientific rationaleand provided new bases for further immunosuppressive strategies.
出版日期Conference proceedings 1999
关键词cancer; clinical trial; immunosuppression; kidney; transplantation
版次1
doihttps://doi.org/10.1007/978-94-011-4643-2
isbn_softcover978-94-010-5960-2
isbn_ebook978-94-011-4643-2
copyrightSpringer Science+Business Media Dordrecht 1999
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Minimal standards for reporting clinical trial results in transplantationbenefit of that therapy. Not all therapeutic decisions in medicine are based on the results of clinical trials. For example, insulin is the standard treatment of diabetic ketoacidosis, even though this therapy was never tested in a randomized controlled trial. Similarly, the need to use immunosuppre
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Factors influencing long-term allograft survival the steady attrition of transplanted organs due to chronic rejection. The UNOS published half-life for cadaveric renal allografts is approximately 8.5 years, not significantly different from the 7.7 year half-life published for cadaveric renal allografts under azathioprine-prednisone immunosuppress
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Cardiovascular complications after renal transplantation than 49.2% by death with a functioning graft, while other causes account for a further 9.4%. Thus, reduction of cardiovascular death will be a very efficient measure to preserve grafts. According to the EDTA Registry [2], the frequency of death from cardiovascular causes increases markedly with age
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Strategies to minimize nephrotoxicity associated to calcineurin inhibitorsclosporine and tacrolimus has been reported [1–3]. Mihatsch et al. [4] found that the side effect pattern of these drugs is nearly identical: they were unable to differentiate morphological changes associated with their clinical nephrotoxicity.
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