Titlebook: Immunostimulatory DNA Sequences; Eyal Raz Book 2001 Springer-Verlag Berlin Heidelberg 2001 Antigen.DNA.apoptosis.asthma.bacteria.biology.c

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Mechanisms of immune stimulation by bacterial DNA,, DNA from bacterial sources displays powerful immunostimulatory activities that rival those of endotoxin in their range and potency. These activities result from short sequence motifs, termed CpG motifs or immunostimulatory sequences (ISSs), that occur much more commonly in bacterial than mammalian

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Rescue of B cells from apoptosis by immune stimulatory CpG DNA,f unneeded cells during development as well as to eliminate infected or damaged cells that could pose a threat to organismal integrity. The immune system also uses apoptosis as a means to regulate cell numbers. For example, at the end of an immune response large numbers of antigen-specific lymphocyt

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The response of human B lymphocytes to oligodeoxynucleotides,ructures, including denatured DNA, Z-DNA, A-DNA, and triple helical DNA [1], it was difficult to induce antibody by immunization with native right-handed helical DNA. Therefore, DNA was generally considered to be poorly immunostimulatory.

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Signal transduction induced by immunostimulatory CpG DNA,characteristic of microbes, but are not present in vertebrates. This detection is accomplished by the means of pattern recognition receptors (PRR). Unlike some other examples of PRR, immune recognition of CpG DNA appears to require cell uptake and to be accomplished through an intracellular PRR syst

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