Titlebook: Immunopathology of Insulin; Clinical and Experim Konrad Federlin Book 1971 Springer-Verlag Berlin · Heidelberg 1971 animals.hormone.immune

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General Summary, humoral antibodies and the hitherto sparse studies of the delayed immune reaction to insulin. To this section some general aspects of cell-mediated immunity were added. Furthermore, examples were given of the clinical symptoms of the various forms of insulin allergy and insulin resistance.

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Ardent

Investigations of the Delayed Immune Reaction and Formation of Antibody to Insulin in Experimental ults. The guinea pig was selected as the experimental animal, because this species, in contrast to numerous other kinds of animals, resembles man in its ability to reproduce a florid immune reaction of the delayed type as well as to produce humoral antibodies.

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0077-1015 ed by allergy. In 1956 it became possible to determine quantita­ tively the insulin-binding antibodies which are responsible for the resistance to insulin. The methods developed since then make it possible to measure minute amounts of the pancreatic hormone in blood and extracellular fluids. There h

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Expiration

Brief Review of the Immunology of Insulin, antigen. On the one hand, hormones were not regarded as antigens due to their species-unspecific biological activity, while on the other hand, insulin is a very small molecule in comparison with other proteins. Indeed, . (1937) was able to demonstrate that guinea-pig uterus, immunized with bovine o

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