| 书目名称 | Immunopathology of Insulin |
| 副标题 | Clinical and Experim |
| 编辑 | Konrad Federlin |
| 视频video | |
| 丛书名称 | Monographs on Endocrinology |
| 图书封面 |  |
| 描述 | Soon after the discovery of insulin in 1922, it became clear that the use of this hormone in the treatment of diabetics is often accom panied by allergy. In 1956 it became possible to determine quantita tively the insulin-binding antibodies which are responsible for the resistance to insulin. The methods developed since then make it possible to measure minute amounts of the pancreatic hormone in blood and extracellular fluids. There have been many attempts to relate insulin allergy and in sulin resistance to the primary, secondary or tertiary structure of the or B chains, or both, and more recently, to the proinsulin which is A present in all commercial preparations of insulin, i. e. to the species specific structure of the C peptide. In the great majority of papers dealing either with the immunogenic and antigenic properties of in sulin or with the relevant antibodies, the discussion has been restricted to the humoral antibodies. The existence of a brief period of delayed local allergy resulting from the cellular immune response has more or less escaped attention. It is specifically this period of delayed allergy that attracted the interest of Dr. FEDERLIN and his colleagues. |
| 出版日期 | Book 1971 |
| 关键词 | animals; hormone; immune response; immunity; insulin; pathology; peptides |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-80608-7 |
| isbn_softcover | 978-3-642-80610-0 |
| isbn_ebook | 978-3-642-80608-7Series ISSN 0077-1015 |
| issn_series | 0077-1015 |
| copyright | Springer-Verlag Berlin · Heidelberg 1971 |
发表于 2025-3-21 17:58:52
