Titlebook: Immunoinformatics; Christian Schönbach,Shoba Ranganathan,Vladimir Bru Book 2008 Springer-Verlag New York 2008 Annotation.Antigen.Chemokine

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Plasticity of Dendritic Cell Transcriptional Responses to Antigen: Functional States of Dendritic Cis should allow modeling of immune system function. Dendritic cells orchestrate the host immune response. By identifying a pathogen and processing this information through a coordinated differentiation program, phenotypic changes effected in dentritic cells allow appropriate information to be convey

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从容

Structural Immunoinformatics,uence-structure-function information is critical in facilitating the understanding of principles governing MHC-specific peptide recognition and binding. Three-dimensional structures of bound peptide ligands to MHC receptors are today characterized in great number using X-ray crystallography, offerin

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, QSAR-Based Predictions of Class I and Class II MHC Epitopes,Histocompatibility Complex (MHC) binding affinity based on QSAR technology have now become important components of modern computational immunovaccinology. Historically, such approaches were built around semiqualitative, classification methods, but these are now giving way to quantitative regression

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Immunoinformatics Applied to Modifying and Improving Biological Therapeutics,are. Although their promise of targeted therapy is a major medical advance, repeated administrations in many cases lead to development of antitherapeutic antibodies that compromise treatment. Multiple sources of immunogenicity are considered in this chapter with a focus on the T-cell-dependent immun

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Plasticity of Dendritic Cell Transcriptional Responses to Antigen: Functional States of Dendritic Ct. To do this the immune system must gather information about the ‘nonself’ pathogens and by processing this information, initiate an appropriate immunological response. The immune system represents an example of emergent behavior from a complex, multifactorial, adaptive system. To understand emerge