| 书目名称 | Immunogenetics of Autoimmune Disease | | 编辑 | Jorge Oksenberg,David Brassat | | 视频video | | | 概述 | All chapters written by experts in the field.Summarizes latest advancements in the field.Essential reading for both immunologists and neuroscientists.Applications for researchers as well as medical pr | | 丛书名称 | Medical Intelligence Unit | | 图书封面 |  | | 描述 | utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases ar | | 出版日期 | Book 2006 | | 关键词 | autoimmune disease; autoimmunity; diseases; genetics; genome; immunity | | 版次 | 1 | | doi | https://doi.org/10.1007/978-0-387-39926-3 | | isbn_softcover | 978-1-4899-9748-7 | | isbn_ebook | 978-0-387-39926-3 | | copyright | Springer-Verlag US 2006 |
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发表于 2025-3-21 18:21:30
