Titlebook: Immune Infertility; Impact of Immune Rea Walter K.H. Krause,Rajesh K. Naz Book 2017Latest edition Springer International Publishing Switzer

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Book 2017Latest editionsections focusing onSperm antigens, Antisperm antibodies (ASAs),  Clinical impact of ASAs,and Immune contraception,  and include contributions from leadingexperts in these fields. This new edition of the book offers acomprehensive update that reflects the very significant advances inreproductive imm

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The Immune Privilege of the Testistrolling immune privilege seem to involve factors that also control spermatogenesis and steroidogenesis. They appear to include androgens, a delicate balance of immunomodulatory molecules such as cytokines and chemokines and a polarizing capacity of the testicular interstitial fluids towards a tolerogenic M2 phenotype.

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Tests for Sperm AntibodiesSA in seminal fluid using the mixed antiglobulin reaction and immunobead tests can be significantly associated with unexplained infertility. On the other hand, testing of seminal plasma or serum was found to be less relevant for fertility assessments.

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Sperm Functions Influenced by Immune Reactionsf the ASA. The usual technique for their identification is 2D-Western blot and MALDI protein analysis. A great variety of antigens are responsible for sperm agglutination, sperm apoptosis and inhibition of sperm motility. Impairment of migration in the cervix mucus appears mostly to be independent f