Titlebook: Images of Biologically Active Structures in the Immune System; Their Use in Biology Hilary Koprowski (Director),Fritz Melchers Book 1985 Th

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Network Regulation of the Immune Response to Bacterial Polysaccharide Antigens,1971; . and . 1977; . et al. 1983). In adults and in children over the age of 2 years this can readily be accomplished by the use of polysaccharide vaccines (. et al. 1977; . et al. 1977; . et al. 1980; . et al. 1983). Infants, however, are unresponsive to most polysaccharide antigens (. etal. 1973;

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Book 1985n the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind­ ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions con

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Human Antibody Induction to the Idiotypic and Anti-Idiotypic Determinants of a Monoclonal Antibody ase (. 1984a; . etal. 1984). As expected, most patients injected with this Mab produced antibody against the murine immunoglobulin (Ig) but, more germaine to this forum, a significant proportion of this antibody was directed against the antigen binding or idiotypic (Id) portion of the molecule (anti-Id) (. et al. 1984).

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Vaccines from Monoclonal Anti-Idiotypic Antibody: Poliovirus Infection as a Model,ic antibodies has recently attracted great attention (see e.g. . and . 1981 and . 1984). In light of present idiotype (Id) research, it must be considered possible to administer anti-Id antibody (Ab2) exogenously to replace antigen for the induction of specific immune response (see for review, . and . 1983 and . and . 1983).