Titlebook: IGFs in the Nervous System; Eugenio E. Müller Book 1998 Springer-Verlag Italia, Milano 1998 G proteins.IFS-BPs.brain.differentiation.gluco

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New Experimental Models for the Study of IGF and IGF-Binding Protein Action in the Brain,and postnatal growth in vertebrates [1]. The IGF system was initially described and studied in detail under its endocrine aspects. The recent discovery of important paracrine and autocrine IGF signalling has contributed substantially to understanding the complex biological actions of the IGFs. Expre

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The Role of IGF-I in Cerebellar Granule Cell Survival and Terminal Differentiation,]. IGF-I over- expression in transgenic mice induces a marked increase in size and number of neurones in most cerebral areas [2]. The most thorough studies on IGF-I action within the context of brain are those performed in the last decade on cerebellar neuronal populations. In cerebellum, this somat

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Regulation of Oligodendrocyte Development and CNS Myelination by IGF-I: Prospects for Disease Thera myelin, which forms a series of insulating segments or “internodes” separated by uninsulated nodes of Ranvier, action potentials are conducted in saltatory fashion, jumping from one node of Ranvier to the next without depolarizing the axonal membrane covered by the intervening myelin. As a result,

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Neurobiology of rhIGF-I: Rationale for Use in Motor Neuron Disease,iginally identified and isolated based on endocrine and metabolic similarities it shared with insulin, particularly those related to the control of blood sugar. However, intense research has demonstrated that IGF-I is mechanistically, biochemically, and pharmacologically distinct from insulin.