Titlebook: Hypoparathyroidism; Maria Luisa Brandi,Edward Meigs Brown Book 2015 Springer-Verlag Italia 2015 Hypoparathyroidism.Parathyroid hormone.Par

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Phosphate Control of PTH Secretionalance are under the control of a great number of factors. In turn, phosphorus can control all these factors, through a complex network of mechanisms. Among these factors, PTH represents one of the main controllers of phosphorus metabolism, and phosphorus, in turn, has a manifold control of PTH itse

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Role of Magnesium in Parathyroid Physiology compartment, while 1 % is found in the extracellular fluid. Maintenance of total serum Mg. within a narrow range (0.70-1.1 mmol/L) is dependent on the coordinated actions of the kidneys, gut and bone. Ninety percent of intestinal absorption and renal reabsorption of Mg. occurs passively via the par

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G Protein Gsα and , Imprintingediates receptor-activated stimulation of adenylyl cyclase, which catalyzes the generation of the ubiquitous second messenger cyclic AMP. The α-subunit (Gsα) is critical for the function of the stimulatory G protein and its complete loss leads to embryonic lethality. Moreover, mutations of the gene

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PTH and PTHrP: Nonclassical Targetstenance of bone and mineral metabolism. Indeed, they exert their actions through binding the PTH/PTHrP receptor, namely, PTH1R, which is expressed in several tissues other than kidney and bone. While PTH acts as a real hormone and displays endocrine actions, PTHrP acts mainly as a paracrine/autocrin

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