Titlebook: Hyperparathyroidism; A Clinical Casebook Ann E. Kearns,Robert A. Wermers Book 2016 Mayo Foundation for Medical Education and Research 2016

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978-3-319-25878-2Mayo Foundation for Medical Education and Research 2016

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https://doi.org/10.1007/978-3-319-25880-5Familial hypocalciuric hypercalcemia; Hyperparathyroidism; Multiple endocrine neoplasia 1; Multiple end

Maximizer

Severe Primary Hyperparathyroidism,ypocalcemia with a normal or increased parathyroid hormone (PTH) level, hungry bone syndrome, more commonly occurs after parathyroidectomy in the setting of severe, long-standing PHPT and in the presence of associated bone disease. Treatment with calcium and calcitriol may be required for months following surgery.

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Parathyroid Carcinoma,sure or family history of cancer. On clinical examination, she appeared dehydrated and lethargic but was hemodynamically stable. A right-sided firm, irregular, non-tender mass was palpable in the area of the right thyroid lobe measuring approximately 3 cm by examination.

ALIBI

Familial Hypocalciuric Hypercalcemia,ning with a finding of a low urinary calcium to creatinine clearance ratio would suggest familial hypocalciuric hypercalcemia (FHH). Genetic testing of the . gene is available and is helpful in such clinical situations as there is an overlap in the biochemical appearance of PHPT and FHH.

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Medical Management of Primary Hyperparathyroidism,erent than the general population. Bisphosphonates, especially alendronate, can improve bone density but not lower serum calcium. Cinacalcet can lower or normalize calcium but does not improve bone density. Combination therapy may be considered if both effects on bone density and serum calcium are warranted.

传授知识

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Parathyroidectomy Outcomes and Pathology in Primary Hyperparathyroidism,n persistent and recurrent PHPT. Parathyroid hyperplasia is the cause of PHPT in approximately 15 % of patients and is seen in familial parathyroid disorders such as MEN1, MEN2A, MEN4, hyperparathyroidism-jaw tumor syndrome, and familial isolated PHPT.