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Titlebook: Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics; Claude L. Malmendier,P. Alaupovic,H. Bryan Brewer Book

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书目名称Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics
编辑Claude L. Malmendier,P. Alaupovic,H. Bryan Brewer
视频videohttp://file.papertrans.cn/431/430616/430616.mp4
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics;  Claude L. Malmendier,P. Alaupovic,H. Bryan Brewer Book
描述The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the geneti
出版日期Book 1991
关键词Amino acid; Lipid; Oxidation; genes; genetics; metabolism; proteins; transcription; diabetes
版次1
doihttps://doi.org/10.1007/978-1-4684-5904-3
isbn_softcover978-1-4684-5906-7
isbn_ebook978-1-4684-5904-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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