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Titlebook: Hydrophilic Matrix Tablets for Oral Controlled Release; Peter Timmins,Samuel R. Pygall,Colin D. Melia Book 2014 American Association of Ph

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书目名称Hydrophilic Matrix Tablets for Oral Controlled Release
编辑Peter Timmins,Samuel R. Pygall,Colin D. Melia
视频video
概述Explores the technology and techniques required to create a successful hydrophilic matrix drug product that is convenient for patients to use.Discusses drug-excipient and excipient-excipient interacti
丛书名称AAPS Advances in the Pharmaceutical Sciences Series
图书封面Titlebook: Hydrophilic Matrix Tablets for Oral Controlled Release;  Peter Timmins,Samuel R. Pygall,Colin D. Melia Book 2014 American Association of Ph
描述.This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, .Hydrophilic Matrix Tablets for Oral Controlled Release. provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations..
出版日期Book 2014
关键词cellulose ethers; controlled release; drug delivery; excipient; hydrophilic; polymer systems
版次1
doihttps://doi.org/10.1007/978-1-4939-1519-4
isbn_softcover978-1-4939-4827-7
isbn_ebook978-1-4939-1519-4Series ISSN 2210-7371 Series E-ISSN 2210-738X
issn_series 2210-7371
copyrightAmerican Association of Pharmaceutical Scientists 2014
The information of publication is updating

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AAPS Advances in the Pharmaceutical Sciences Serieshttp://image.papertrans.cn/h/image/430497.jpg
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https://doi.org/10.1007/978-1-4939-1519-4cellulose ethers; controlled release; drug delivery; excipient; hydrophilic; polymer systems
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Hydrophilic Matrix Tablets for Oral Controlled Release978-1-4939-1519-4Series ISSN 2210-7371 Series E-ISSN 2210-738X
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Physiologically Based Pharmacokinetic Modeling in the Development and Evaluation of Hydrophilic Maton data as an input for PBPK modeling is described and the development of an in vitro–in vivo correlation (IVIVC) is covered. Finally, the limitations of PBPK modeling applied to hydrophilic matrix tablets are indicated.
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Extrusion: An Enabling Technology for Controlled-Release Hydrophilic Matrix Systems,g step, to simultaneously deliver drug over an extended period, enhance equilibrium drug solubility, and prevent the dissolved drug from precipitating out of saturated solution in the simulated GIT fluids for periods as long as 8 h. Twin-screw extrusion is a versatile enabling technology that is inc
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