Titlebook: Humanized Mice; Tatsuji Nomura,Takeshi Watanabe,Sonoko Habu Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/h/image/429870.jpg

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Basic Concept of Development and Practical Application of Animal Models for Human Diseases,ironmental controls are necessary to ensure reproducibility of experimental results. At the end of this chapter, future aspects of the application of “humanized mice” based on novel super-immunodeficient mice such as NOG mice and .. IL2rrγ. mice in biomedical research and testing are briefly reviewed.

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Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development,NK cells are implicated in the recognition of pathogen-infected cells and in the clearance of certain tumor cells. In this chapter, we discuss NK cell developmental pathways and the use of humanized murine models for the study of human hematopoiesis and, in particular, human NK cell development.

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Novel Metastasis Models of Human Cancer in NOG Mice,ion. In research on cancer metastasis, the . dynamic state of human cancer cells after transplantation into NOG mice is partially identical to that in human beings. This chapter also describes the superiority of NOG mice over conventional immunodeficient NOD/Shi- . mice in cancer research.

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0070-217X nted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and tre

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