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Titlebook: Human T Cell Clones; A New Approach to Im Marc Feldmann,Jonathan R. Lamb,James N. Woody Book 1985 The Humana Press Inc. 1985 AIDS.Antigen.a

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The Murine T Cell Receptores through the use of clone-specific antibodies which recognize idiotypic determinants on T cell antigen receptors. Studies with these antibodies, summarized in a recent review (1) have established that the antigen/MHC recognition structures on T cells (a) are idiotypic molecules as indicated by the
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Cloned HLA-D Genes: Characterisation and Approaches to Expression and Analysis of Functionsponse. This brief paper contains a summary of some of the current studies in this laboratory on the organisation of human Class II genes. Details on the characterisation of six different Class IIα chain genes are presented, including a new gene, DZα, which does not fit into any of the three most cl
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SB-Specific CTL Clones Exhibit Functional Heterogeneity in their Susceptibility to Blocking by Anti-lls that bear the T4 (Leu 3) cell surface marker.. Antibodies that bind the T4 molecule have been shown to block the proliferative and cytotoxic responses of T4. cells to class II MHC antigens.. Studies that have partitioned the cytolytic process into binding and post-binding phases have demonstrate
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Recognition of HLA class II Molecules by Functional Human T-Lymphocyte Clones (TLC’s) argued that class II molecules are somehow involved in controlling or influencing the specificity of T-cell recognition. Remaining unclear, however, is the relationship between T-cell specificity and function. That is, the question of whether particular class II gene products determine discrete imm
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Restriction Elements on Class II HLA Molecules Studied by Cloned Human T4 Cellsst of the TLCs obtained were only able to recognize antigen together with restriction elements on DR molecules, expressed in the antigen-presenting cells (APC). A few TLCs were restricted by elements on DRw53(MT3) molecules, and one TLC by DPw4(SB4) molecules. A close relationship was found between
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HLA-Class I Antigen Recognition by EB Virus-Specific and Allo-Specific Cytotoxic T Cellset antigen on the surface of infected cells not as an isolated structure but in some form of association with the polymorphic determinants of HLA class I gene products (1–3). Thus virus-specific cytotoxic T cells offer a means of probing HLA class I antigen polymorphism which is independent of that
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