Titlebook: Human Retrotransposons in Health and Disease; Gael Cristofari Book 2017 Springer International Publishing AG 2017 Epigenetics.Genome.Germl

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978-3-319-83917-2Springer International Publishing AG 2017

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The Mobilisation of Processed Transcripts in Germline and Somatic Tissues,ences. Annotation of assembled genomes has indicated many thousands of processed pseudogenes, and many subsequent studies have shown them to be highly important material for the evolution of new genes, suggesting that the term ‘pseudogene’ is often a misnomer. It has been shown that these copies ari

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Activity of Retrotransposons in Stem Cells and Differentiated Cells,ributed to the current structure of the human genome in a myriad of ways. Indeed, the activity of TEs is increasingly recognized as a major force in the evolution of eukaryotic genomes. However, TE insertions and TE-mediated genomic rearrangements can become a serious threat to genome stability. TEs

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Environment, Cellular Signaling, and L1 Activity,impacts the structure and dynamics of the genomes they inhabit. In humans, Long INterspersed element 1 (LINE1 or L1) is the main driver of TE activity and TE-linked mutations. Increasing studies suggest that TE activation result from a host response to environmental stimuli. This chapter presents th

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