Titlebook: Human Cytomegalovirus; Thomas E. Shenk,Mark F. Stinski Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Interlocking

Mutagenesis of the Cytomegalovirus Genome,ment in .. Artificial chromosomes are useful for genome sequencing programs, for transduction of DNA segments into eukaryotic cells, and for functional characterization of genomic regions and entire viral genomes such as cytomegalovirus (CMV) genomes. CMV genomes in BACs are ready for the advanced t

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Functional Roles of the Human Cytomegalovirus Essential IE86 Protein,ctivates the viral early and late promoters, and both activates and inhibits cellular promoters. It promotes cell cycle progression from Go/G1 to G1/S and arrests cell cycle progression at the G1/S interface or at G2/?. The IE86 protein is essential because it creates a cellular environment favorabl

vasospasm

Nuts and Bolts of Human Cytomegalovirus Lytic DNA Replication,t comprise two main functional domains. The first is a bidirectional promoter element that is responsive to UL84 and IE2. The second appears to be an RNA/DNA hybrid region that is a substrate for UL84. UL84 is required for oriLyt-dependent DNA replication along with the six core proteins, UL44 (DNA

斗志

Interactions of Human Cytomegalovirus Proteins with the Nuclear Transport Machinery, of herpesviral proteins that are involved in processes such as transcription and DNA replication. The passage of large molecules between the cytoplasm and nucleus, however, is restricted, and this restriction affords specific mechanisms that control nucleocytoplasmic exchange. In this review, we fo

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