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Titlebook: Host Defenses to Intracellular Pathogens; Proceedings of a con Toby K. Eisenstein,Paul Actor,Herman Friedman Conference proceedings 1983 Th

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Oxygen Independent Microbicidal Mechanisms of Human Polymorphonuclear Leukocytesative processes. These include the superoxide anion (O.-), the myeloperoxidase-chloride-hydrogen peroxide system (MPHCl), and free hydroxyl radicals (•OH) (1). The other group (Table 1) functions independently of oxidative processes and includes increased hydrogen ion concentrations, various cationi
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Some Paradoxes of Macrophage Functionas yet unpublished, work from our laboratory is described. In its preparation, I was at first dismayed to realize that it raises so many questions, but answers very few. Still the purpose of such an effort is to arouse interest in what I believe are provocative issues, with the hope that their exami
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Stimulation of Host Resistance to Metastatic Tumors by Macrophage Activating Agents Encapsulated in nt of cancer have stimulated renewed interest in mechanisms of non-specific “natural” antitumor surveillance mediated by macrophages and natural killer cells. A significant effort is now underway in many laboratories to develop effective biological response modifier (BRM) agents that can stimulate t
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Effect of Prostaglandins on the Production of Interleukin-2hat prostaglandins, especially of the E-series, inhibit lectin or antigen-induced lymphocyte proliferation . (2–5). Recently, it has become evident that T-cell proliferation is dependent on the production and utilization of a soluble protein known as T-cell growth factor (TCGF) or Interleukin-2 (IL-
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Guinea Pig Alveolar Macrophages Probably Kill , H37Rv and H37Ra , by Producing Hydrogen Peroxiden the immune animal, can kill . (1) and this might involve the production of hydrogen peroxide (H.O.) by the macrophages. Macrophages release H.O.. when exposed to phagocytic stimuli or certain soluble agents that perturb the plasma membrane (8, 9). H.O. can kill . and resistance to H.O.. correlates
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