Titlebook: Hormones in Ageing and Longevity; Suresh Rattan,Ramesh Sharma Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusive l

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Somatotropic Axis’ Role in Ageing and Longevity Could Depend on Life-History Strategies of Speciesngs. However, this rationale does not take into account the life-history strategies of species and the way they adapt to environmental challenges, particularly to food restriction. It is argued that, for short-lived species of a small size, the best strategy to survive starvation is staying at the s

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Zinc, Insulin and IGF-I Interplay in Aging is an evolutionary conserved pathway involved in many functions that are necessary for metabolism and growth. Notably, the IIS pathway play also a major role in aging. The overall cellular response and the outcome on the longevity of the organism depends also by the mechanisms involved in the regul

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Growth Hormone and IGF-1 Axis in Aging and Longevityions in body composition and thus physical frailty in aging animals. By contrast, attenuation of the GH-IGF-1 axis consistently increases lifespan in a range of animals. Studies using mutant animals reveal key molecules for longevity in cytoplasmic IGF-1 signaling, including mechanistic target of ra

Conflict

Thyroid Function in Healthy Ageing and Longevityce affects up to 1 in 7 older individuals. Reference ranges that determine ‘normal’ thyroid function has been predominantly obtained from younger populations. But, recent data from observational studies suggest that serum thyrotropin levels increase in older people and this change does not seem to b

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Hormones of Hypothalamus in Agingf aging. Moreover, the endocrinological basis of aging in male and female organisms is very complex, with multiple hormones along the hypothalamic-pituitary (HP) axis interacting with each other via different feedback loops to maintain homeodynamic state. Also the sensitivity of the hypothalamus to

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Environmental and Physiological Cues on the Hypothalamus During Agingtem with the endocrine system. The hypothalamus regulates development, growth, and metabolism, and is considered to have a key role in the progression of whole-body aging. Multiple environmental and physiological signals can adversely affect hypothalamic function leading to cellular senescence. The

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