Titlebook: Histone Deacetylases; Transcriptional Regu Eric Verdin Book 2006 Humana Press 2006 biochemistry.biology.cell.enzymes.proteins.vertebrates

modifier

Cell Cycle Targets of Histone Deacetylase Inhibitorse yet to be absolutely identified. These cell cycle effects are the basis of the antiproliferative activity and tumor cell selectivity of these drugs, properties that potentially make them highly effective anticancer drugs.

使困惑

Regulation of Muscle Gene Expression by Histone DeacetylasesIn addition, we describe work that established roles for a subset of HDACs as signal integrators that couple cues emanating from the cell surface to muscle-specific genes in the nucleus, and we speculate on the potential to manipulate these regulatory cascades with small molecules as a means to treat cardiac and skeletal myopathies.

确定方向

The Class IIa Histone Deacetylasest transcriptional repressor yRPD3, whereas class II HDACs are related to yHDA1 and class III HDAs to ySIR2. In this review, we focus on the structure and function of class IIa HDACs. These recently discovered enzymes have been implicated as important regulators of gene expression during cell differentiation and development.

Tortuous

Histone Deacetylases in the Response to Misfolded Proteinsl’s response to misfolded proteins. Using the characterization of HDAC6 as a starting point, in this chapter we review the role of HDACs in the cellular response to misfolded proteins. Specifically, we address how HDACs regulate the formation of aggresomes. We also discuss the relevance of these findings to neurodegenerative disease.