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Titlebook: Histone Deacetylases; Transcriptional Regu Eric Verdin Book 2006 Humana Press 2006 biochemistry.biology.cell.enzymes.proteins.vertebrates

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发表于 2025-3-21 17:56:05 | 显示全部楼层 |阅读模式
书目名称Histone Deacetylases
副标题Transcriptional Regu
编辑Eric Verdin
视频video
概述Includes supplementary material:
丛书名称Cancer Drug Discovery and Development
图书封面Titlebook: Histone Deacetylases; Transcriptional Regu Eric Verdin Book 2006 Humana Press 2006 biochemistry.biology.cell.enzymes.proteins.vertebrates
描述A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
出版日期Book 2006
关键词biochemistry; biology; cell; enzymes; proteins; vertebrates
版次1
doihttps://doi.org/10.1385/1597450243
isbn_softcover978-1-61737-602-3
isbn_ebook978-1-59745-024-9Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightHumana Press 2006
The information of publication is updating

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Biochemistry of Multiprotein HDAC Complexesfic restrictions to transcription and contributes to the proper coordination of gene expression. In order to perform these functions and to achieve proper modulation of their activity, HDACs associate with other proteins, and in some cases, even with themselves. The purification and analyses of thes
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Regulation of Muscle Gene Expression by Histone Deacetylaseseby limits access of basal transcriptional machinery to gene regulatory elements. In the past 5 years, HDACs have emerged as key regulators of gene expression in muscle. In this chapter, we discuss the initial findings linking HDACs to the control of striated muscle cell differentiation and growth.
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Evolution of Sirtuins From Archaea to Vertebratesd the echinoderm sea urchin ., there are seven sirtuins. Class I includes SIRT1, SIRT2, and SIRT3. SIRT4 is in class II and SIRT5 is in class III. Class IV includes SIRT6 and SIRT7. Fish have two SIRT5 orthologs while most other vertebrates have only one version of each of the seven sirtuins. Arthro
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The Enzymology of SIR2 Proteinse, the deacetylated product, and .-acetyl-ADP-ribose. An increasing number of cellular processes including apoptosis, cell cycling, gene silencing, and longevity, have been shown to be dependent and regulated by these deacetylases. Several small molecules have been identified as regulators of Sir2 a
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The Class III Protein Deacetylasesiptional regulator Sir2. In eukaryotes, sirtuins regulate The first two authors contributed equally to this review. transcriptional repression, recombination, cell cycle division, microtubule organization, and cellular responses to DNA-damaging agents. Sir2 proteins have also been implicated in regu
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