Titlebook: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders; Shabir Ahmad Ganai Book 2019 Springer Nature Singapore Pte Ltd. 2019

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Current Challenges with HDAC Inhibitor-Based Therapeutic Intervention Against Neurological Maladiesand high structural identity at the active sites of different HDACs. Importantly, the lack of blood-brain barrier permeability of HDACi restricting the use of these marvellous inhibitors against neurological disorders is detailed.

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rders.It uniquely highlights the potential of various HDAC i.This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging tar

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Different Groups of HDAC Inhibitors Based on Various Classifications,n and source. Further, the detailed account of various approved HDACi for treating various malignancies will be given. Notably, I will discuss the different structural components of a typical HDAC inhibitor.

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HDAC Inhibitors as Novel Therapeutic Option Against Therapeutically Challenging Neurological Disordfect of various HDACi against neurological disorders including Alzheimer’s disease, Parkinson’s disease, and epilepsy. The underlying molecular players modulated by these inhibitors in bringing therapeutic effect will also be taken into consideration.

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Epigenetics and its Implications in Neurological Disorders,one proteins undergo. Moreover, the altered activity and expression of various epigenetic enzymes in distinct neurological disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS) will be thoroughly discussed.

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Designing of Selective and Brain-Penetrant HDAC Inhibitors for Effective Therapy Against Neurologiccomputational and medicinal chemistry approaches for designing selective HDAC inhibitors. Further, the chapter also gives bird’s eye view on image-guided approach for identifying the brain-penetrant HDACi.

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