Titlebook: High Content Screening; D. Lansing Taylor,Jeffrey R. Haskins,Kenneth A. Gi Book 2006 Humana Press 2006 bioinformatics.biology.cell biology

恶心

Differentiating Primary Human Cells in Rapid-Throughput Discovery Applicationsing reliable supplies of primary cells on a large scale has been problematic. Here, two primary differentiating cell types, preadipocytes and preosteoclasts, are described to illustrate the utility of commercially produced cell systems in discovery research and rapid-throughput applications.

常到

Use of the CellCard™ System for Analyzing Multiple Cell Types in Paralleles to be assayed within a single microtiter well allowing for the simultaneous determination of cellular activity and compound selectivity. This chapter will describe a method by which multiple cell types can be simultaneously assayed for biological parameters of interest.

嬉耍

Reagents to Measure and Manipulate Cell Functionse same living cells. The use measurement and manipulation reagents in multiplexed high content screening assays promises to enable a systems cell biology approach to drug discovery and biomedical research.

ARIA

Exploiting Network Biology to Improve Drug Discoveryathways. Here we describe the utility of this novel strategy for high-throughput screening of known targets, and for screening previously undrugable targets and profiling drug leads for improved selectivity and safety.