Titlebook: Hierarchische Mittelwert- und Kovarianzstrukturmodelle mit nichtmetrischen endogenen Variablen; Ulrich Küsters Book 1987 Physica-Verlag He

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Ulrich Küstersiological mechanisms such as DNA molecular rearrangements in multiple loci (three for IG and four for TR in human) located on different chromosomes (four in human), nucleotide deletions and insertions at the rearrangement junctions (or N-diversity), and somatic hypermutations in the IG loci (for rev

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Ulrich Küsters Padlan et al. (.), Stanford and Wu (.), and Feldmann et al. (.). Following the essentially “homology”-based predictions of these early approaches, methods were developed that introduced more rule-based procedures exemplified by our own work (.–.) and that of Chothia, Lesk, and colleagues (.–.) who,

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Ulrich Küsters available from hybridoma cell lines. Here, a method is presented to obtain the genetic information for the antigen binding part of the antibody from hybridoma cells, and to assemble it into a functional bacterially expressed fusion protein (scFv fragment). To achieve this, vectors have been constru

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Ulrich Küstersle, an immense number of different molecules, bearing different specificities, is required. This diversity is generated by somatic recombination and hypermutagenesis of a set of variant genes. The genetic information for this repertoire of different antibodies is stored in the B-cell pool of our lym

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number of protocols.With both new and well established techAntibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, ef

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Ulrich Küstersas e. g. in the case of intoxication. In this situation, therapeutic antibodies can be applied to help our own immune system. Further, therapeutic antibodies against self-antigens can be employed to modulate targets not related to an immune challenge, e. g. to interfere with endogenous regulation processes.

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