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Titlebook: Heritage in War and Peace; Legal and Political Gianluigi Mastandrea Bonaviri,Mirosław Michał Sado Book 2024 The Editor(s) (if applicable)

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Moirika Reker,Rui Maia Regove heart failure. The development of losartan, a biphenyltetrazole derivative, was based on a carefully managed, rational drug design aimed at improving the low-oral bioavailability normally observed with peptide antagonists. The drug was also designed to preserve selectivity at the AT. receptor sit
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Eric Wiebelhaus-Brahm,S. Ra’phael Davis in the vascular and cardiac remodeling observed in response to chronic or acute hypertension. Two major Ang II receptor subtypes, AT. and AT., have been described, and their roles in vivo and in vitro have now been investigated using nonpeptidic antagonists, losartan and PD123319, which block AT. a
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Sabrina Ferrazziowing investigators to generate germ line mutations in selected genes. Since the introduction of this technology in the early 1980s, hundreds of genes have been targeted for systemic deletion (knocked out), including each gene of the renin-angiotensin system (RAS). Although the technique is very pow
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Lucas Lixinski,Sarah Williamstors). . factors are sequence-specific DNA-binding proteins that recognize specific signatures in base composition of the DNA, and upon binding, are able to influence transcriptional activity of the core promoter by multiple diverse mechanisms. These mechanisms include direct interaction with the pr
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Kamil Zeidler,Aleksandra Gussg, and protein trafficking. There are several well-characterized in vitro translation systems including mammalian cell extracts (e.g., HeLa cells and Chinese Hamster Ovary cells) (.,.), rabbit reticulocyte lysates (.,.), . egg extracts (.), rye embryo (.), and wheat germ (.,.) that efficiently and f
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