Titlebook: Hereditary Breast and Ovarian Cancer; Molecular Mechanism Seigo Nakamura,Daisuke Aoki,Yoshio Miki Book 2021 Springer Nature Singapore Pte

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Chemoprevention for Breast Cancer,eoplastic diseases. Although the precise mechanisms that promote breast cancer are not fully understood, several recent clinical trials suggest that chemoprevention is a rational and attractive strategy for selected high-risk populations in a prophylactic setting. Conventionally, endocrine intervent

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Risk-Reducing Salpingo-oophorectomy (RRSO), (HBOC) syndrome. When HBOC is diagnosed without ovarian cancer, surveillance is performed using transvaginal ultrasound and serum CA125 assessment, and chemoprophylaxis is administered using oral contraceptives (OCs) or low-dose estrogen–progestin (LEP); however, RRSO is the most reliable treatment

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Panel Testing,ties found in tumors and provide medical interpretation, have been implemented in routine clinical practice. For standard treatment-resistant solid tumors, two panel tests were authorized in Japan. Although the primary outcome of these panel tests is to find a way for possible treatment options, in

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Germline Findings from Genetic Testing for Breast Cancer,n cancer (HBOC), caused by loss-of-function germline mutation of tumor suppressor genes . and ., is the best known, but many other causative genes of hereditary breast cancer are also recognized. Accurate diagnosis of hereditary cancer not only provides patients with more appropriate surveillance an

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Ethical Issues: Overview in Genomic Analysis and Clinical Context,f, we discuss ethical considerations in the context of decision-making on genetic testing, debates on incidental/secondary findings (IFs/SFs), and global trends in clinical and/or genetic data sharing, including with patients and their family members. In the second half, from the perspective of clin

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