Titlebook: Hereditary Breast and Ovarian Cancer; Molecular Mechanism Seigo Nakamura,Daisuke Aoki,Yoshio Miki Book 2021 Springer Nature Singapore Pte

摘要记录

Ethical Issues: Overview in Genomic Analysis and Clinical Context,r patients. This includes disclosure of genetic information with genetic relatives, and challenges in family communication, in which carefully assessed and encouraging support may be needed for patients and family members.

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History, Advancements, and Future Strategies,enes. Furthermore, treatment strategies and prevention care options to reduce the overall risk for hereditary cancers have been established based on rapid advancements in gene sequencing. Owing to the great efforts of our predecessors, the quality of life of patients diagnosed with hereditary tumors

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Molecular Basis of BRCA1 and BRCA2: Homologous Recombination Deficiency and Tissue-Specific Carcinoenomic stability. One particularly important function of these genes is the homologous recombination (HR) repair of DNA. HR repair is an essential error-free repair mechanism for DNA double-strand breaks that utilizes an intact sister chromatid as a template. In addition to its role in HBOC oncogene

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Genetic Testing,esting is performed. Genetic testing has a variety of purposes, including HBOC diagnosis, companion diagnosis, relative diagnosis, carrier diagnosis, and confirmation of secondary findings. Who is the best test candidate depends on the purpose of the test. Various sizes of BRCA1/BRCA2 variants have

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Variants of Uncertain Significances in Hereditary Breast and Ovarian Cancer, cancers. Detection of a . or . pathogenic variants by genetic testing triggers several clinical management approaches, such as surveillance and prophylactic surgery for healthy carriers, and chemotherapy using poly (ADP-ribose) polymerase (PARP) inhibitors for patients with cancer. Therefore, accur

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Hereditary Ovarian Cancer,BOC) syndrome. Genetic testing for . and . is used not only for a diagnosis for HBOC but also a biomarker for PARP inhibitors, which is of great importance in the treatment of ovarian cancer. The characteristics of ovarian cancer in HBOC have been reported of the highest prevalence in high-grade ser

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