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Titlebook: Hemostatic Mechanisms and Metastasis; Kenneth V. Honn,Bonnie F. Sloane Book 1984 Martinus Nijhoff Publishing, Boston 1984 carcinoma.cell.c

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Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells,Clinical laboratory findings have demonstrated a number of hemostatic abnormalities indicating an overt or low grade activation of the clotting system in malignant disease, even in the absence of hemorrhagic or thrombotic signs (8–13).
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Arachidonate Metabolism in Platelets and Blood Vessels,f experiments established that essential fatty acids were precursors of prostaglandins (7–9), Dihomo-γ-linolenic acid is the precursor of “1” series prostaglandins; arachidonic acid is the precursor of “2” series prostaglandins and 5,8,11,14,17-eicosapentaenoate is the precursor of “3” series prostaglandins.
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Overview of the Metastatic Cascade,only comparatively few were recognized. This is particularly true for metastasis, where we are currently at the stage of recognizing at least some of the basic problems, and hopefully can begin to arrive at some of their solutions.
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Evidence for a Tumor Proteinase in Blood Coagulation,vide perspective about the evidence that led investigators to look for procoagulants associated with malignant tissue. The following discussion will review tumor-derived procoagulants with emphasis on evidence for a unique tumor-derived proteolytic enzyme that initiates blood coagulation (for further evidence see Chapter 12).
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Perspectives on the Role of Platelets in Hemostasis and Thrombosis, vessel wall cells, plasma coagulation factors and circulating blood cells to modulate hemostasis. In this review we will discuss platelet adhesion, the platelet release reaction, platelet aggregation, the effects of these phenomena on the coagulation system and their importance in hemostasis and thrombosis.
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