Titlebook: Hemopoietic Colonies; In Vitro Cloning of Donald Metcalf Book 1977 Springer-Verlag Berlin · Heidelberg 1977 cell.diseases.hematology.leuke

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General Discussion,systems, it should now be possible to analyze most of the biological processes occurring as progenitor cells proliferate and differentiate to eventually form the mature end cells in each hemopoietic subpopulation.

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Donald Metcalf M.D., F.A.A.Let . be a natural number and let .=(.,…,.) and .=(.,…,.) be vectors with non-negative components; moreover, let m. ≥ 0,…, m. ≥ 0 be integers. Further, let .(.)=(.(.),….()) be an entire vector-valued function.

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Donald Metcalf M.D., F.A.A.Let . be a natural number and let .=(.,…,.) and .=(.,…,.) be vectors with non-negative components; moreover, let m. ≥ 0,…, m. ≥ 0 be integers. Further, let .(.)=(.(.),….()) be an entire vector-valued function.

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Let . be a natural number and let .=(.,…,.) and .=(.,…,.) be vectors with non-negative components; moreover, let m. ≥ 0,…, m. ≥ 0 be integers. Further, let .(.)=(.(.),….()) be an entire vector-valued function.

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Colony Formation by Myeloid Leukemic Cells,Following the demonstration that normal progenitor cells of neutrophils and monocyte-macrophages could be cloned in semisolid cultures, extensive studies have been made on the capacity of the neoplastic equivalents of these cells to proliferate in agar.

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Eosinophil Colony Formation,Eosinophil colony formation in vitro was first described by . et al [53] and . and . [13] in cultures of human marrow and peripheral blood cells. These observations were confirmed and extended by several groups working with cultures of human marrow cells [86, 57, 75].

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Erythroid Colony Formation,Short-term liquid cultures of marrow erythropoietic cells have been used extensively to monitor erythropoietin-dependent heme synthesis, but it is doubtful whether such cultures can support significant erythropoietic proliferation.

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