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Titlebook: Heme and Hemoproteins; Francesco Matteis,W. Norman Aldridge Book 1978 Springer-Verlag Berlin Heidelberg 1978 Arzneimittelnebenwirkung.Bili

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书目名称Heme and Hemoproteins
编辑Francesco Matteis,W. Norman Aldridge
视频video
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: Heme and Hemoproteins;  Francesco Matteis,W. Norman Aldridge Book 1978 Springer-Verlag Berlin Heidelberg 1978 Arzneimittelnebenwirkung.Bili
描述The study of the biological effects of foreign chemicals (whether therapeutic drugs or chemicals present at work or in the environment) interests the biologist from a number of different and complementary viewpoints. Apart from the more obvious pharmacological and toxicological interest, the experimentalist often uses foreign chemicals to produce in experimental animals disease states similar to naturally occurring diseases, so that their pathogenetic mechanisms and therapy can be studied under controlled conditions. In addition - as Claude Bernard pointed out over a century ago - foreign chemicals can be employed as instruments to analyze the most delicate vital processes; much can be learned about the physiological processes themselves by a careful study of the mechanisms by which these are altered by chemicals. The field of heme and hemoproteins offers an example of the interplay of these different approaches. Their metabolism can be altered by therapeutic drugs and other foreign chemicals and this results in a variety of biological responses that transcend the boundaries of pharmacology into the confines of clinical medi­ cine, genetics, toxicology, biochemistry and physiology.
出版日期Book 1978
关键词Arzneimittelnebenwirkung; Bilirubin; Biosynthese; Eiweiss; Häm; Leber; Pharmakologie; Porphyrie; therapy
版次1
doihttps://doi.org/10.1007/978-3-642-66763-3
isbn_softcover978-3-642-66765-7
isbn_ebook978-3-642-66763-3Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1978
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Effects of Drugs on Bilirubin Metabolism,Type I: A hereditary disorder of bilirubin metabolism in which bilirubin glucuronyl transferase activity is lacking abd the bile is free of bilirubin glucuronide. Severe unconjugated hyperbilirubinemia usually leads to kernicterus in infancy.
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Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism, Several steps of the heme biosynthetic chain are subject to the toxic effects of lead. ALA-dehydratase and ferrochelatase, in particular, are two enzymes which are strongly inhibited by lead, leading to decreased heme synthesis.
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Induction of Hepatic Hemoproteins,ll as by the administration of various chemicals foreign to the body. In particular, the level of a hepatic hemoprotein, microsomal cytochrome P-450, is increased by the administration of a wide variety of lipid-soluble xenobiotics (e.g., drugs, insecticides, herbicides, and carcinogenic poly cyclic
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