Titlebook: Hematopoietic Growth Factors in Oncology; Gary H. Lyman,David C. Dale Book 2011 Springer Science+Business Media, LLC 2011 Biology.Molecula

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Erythropoiesis-Stimulating AgentsBCs contain hemoglobin, the main oxygen carrying component in blood. The large number of RBCs found in blood is required to support the prodigious consumption of oxygen by tissues as they undergo oxygen-dependent processes. Erythropoietin is a hormone that when it binds and activates Epo receptors r

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Thrombopoietin Factorsality factor in several diseases and represents a significant unmet medical need. Since the discovery of thrombopoietin (TPO) as the primary physiological regulator of megakaryopoiesis, a number of therapeutics have been developed for thrombocytopenia and been tested in preclinical models and human

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Meta-Analysis of Randomized Controlled Trials of Granulocyte Colony-Stimulating Factor Prophylaxis ial phase III trial in patients with small cell lung cancer, patients were randomized to either G-CSF or placebo following combination chemotherapy in a double-blind fashion [3]. A significant difference in the cumulative risk of febrile neutropenia (FN) between the control (77%) and the G-CSF (40%)

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Randomized Controlled Trials of the Erythroid-Stimulating Agents in Cancer Patients chemotherapy and have presented difficult challenges to the management of these patients. Anemia is particularly common [1] and is usually multifactorial, with the major contributing factors including the disturbances in iron metabolism associated with chronic inflammatory illness [2–5] and the mye