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Titlebook: Hematological Disorders in Children; Pathogenesis and Tre Eiichi Ishii Book 2017 Springer Nature Singapore Pte Ltd. 2017 Childhood.Infant.M

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发表于 2025-3-21 19:49:33 | 显示全部楼层 |阅读模式
书目名称Hematological Disorders in Children
副标题Pathogenesis and Tre
编辑Eiichi Ishii
视频video
概述Describe the pathogenesis and treatment of several representative hematological disorders in children.Special focus on the genetic and molecular aspects of childhood hematological disorders.Broadens r
图书封面Titlebook: Hematological Disorders in Children; Pathogenesis and Tre Eiichi Ishii Book 2017 Springer Nature Singapore Pte Ltd. 2017 Childhood.Infant.M
描述 This book describes the pathogenesis and treatment of several representative hematological disorders in children, with a special focus on genetic and molecular aspects. Research on the pathogenesis of hematological disorders in children has made remarkable strides; especially molecular target therapy has shown outstanding effects in refractory and conventional therapies for childhood leukemia. The findings presented in this book will broaden readers’ understanding and hopefully spark new discussions leading to the development of new therapies including cell therapy and molecular target therapy, allowing clinicians to use more effective and less toxic approaches in the future.. Hematological Disorders in Children .will appeal to a wide readership, from medical students and beginning investigators to experienced scholars in the field of pediatric hematology and oncology seeking to broaden their understanding and keep up with the latest developments. It will also beof interest to the parents of pediatric patients, and to co-medical staffs..
出版日期Book 2017
关键词Childhood; Infant; Molecular Target Therapy; Anemia; Leukemia; Hemophilia; Thrombosis; LCH
版次1
doihttps://doi.org/10.1007/978-981-10-3886-0
isbn_softcover978-981-10-9992-2
isbn_ebook978-981-10-3886-0
copyrightSpringer Nature Singapore Pte Ltd. 2017
The information of publication is updating

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发表于 2025-3-21 21:32:01 | 显示全部楼层
Eiichi IshiiDescribe the pathogenesis and treatment of several representative hematological disorders in children.Special focus on the genetic and molecular aspects of childhood hematological disorders.Broadens r
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Hematopoietic Stem Cells: The Basis of Normal and Malignant Hematopoiesisd transit through several different tissues, including the yolk sac, aorta-gonad-mesonephros (AGM) region, placenta, and fetal liver, before colonizing in the bone marrow where they reside throughout the individual’s life. HSCs, characterized by the ability to self-renew and generate all types of bl
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Acute Lymphoblastic Leukemiak-stratified multi-agent chemotherapy through cooperative clinical trials worldwide, survival rate of childhood ALL increased from less than 10% in the 1960s to approximately 90% nowadays. Recent advance in genomic analyses is rapidly increasing our understanding of the pathobiology of ALL, which ma
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Acute Myeloid Leukemiaes, survival rates have currently reached approximately 70% in de novo AML and 80% in myeloid leukemia associated with Down syndrome and acute promyelocytic leukemia (APL). Advance in genomic analyses would contribute to further understanding of the pathobiology of AML, which is expected to result i
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Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)e proportion of blasts in the bone marrow (BM) and peripheral blood, it is divided into low-grade MDS and advanced MDS. Low-grade MDS often shows hypocellular BM, which makes differentiation from aplastic anemia and inherited bone marrow failure syndrome challenging. Treatment strategy for low-grade
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Neutropenia (In Infancy and Childhood)00/μL. Chronic neutropenia in pediatric patients is divided into three groups. Extrinsic factors, such as antibodies, some drugs, and nutritional deficiencies, lead to excessive destruction of neutrophils. Autoimmune neutropenia is a benign form of neutropenia shown in infancy to early childhood. Sp
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Childhood Aplastic Anemias. Of note, development of the next-generation sequencing has identified minor clones and novel somatic mutations in AA. As a result, clonal hematopoiesis in AA has become widely recognized. The mechanism of disease progression from AA to myelodysplastic syndrome/acute myelogenous leukemia has been
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